To inform the responses to infectious disease outbreaks at institutions of higher education, I worked with ISyE professors and other graduate students at Georgia Tech to build a co-enrollment network, which is a representation of student connections through courses, and investigate the impacts of various hybrid instructional mode strategies on the co-enrollment network. To evaluate these strategies from health and academic perspectives, we developed network connectivity and in-person instruction metrics. After quantifying these metrics, we compared these strategies in terms of network connectivity, in-person instruction, by their impacts on various groups of students, and based on the trade-off between network connectivity and in-person instruction. Here is the link to the working paper: https://osf.io/jp6aq/